An example is extra doses of pneumococcal vaccines for people with haematological malignancy. People who are immunocompromised may need extra doses of inactivated vaccines to optimise protection against specific diseases. Assessing the need for extra vaccine doses Seek expert advice from their treating physician or an immunisation specialist.ДЇor more details about assessing the level of immunocompromise to determine whether people can receive live vaccines, see Use of specific live vaccines in people who are immunocompromised. If there is uncertainty about how severely a person is immunocompromised and whether it is safe for them to receive a vaccine, do not vaccinate them. anticipated duration of the personвЂ™s immunocompromised state, whether due to the therapy or the underlying disease.consequence of using combination therapies - for example, corticosteroids and other immunosuppressive therapies such as DMARDs (disease-modifying anti-rheumatic drugs), which can contribute to the nature, extent and length of the immunocompromising condition.mechanism, and duration of the effect on the immune system, of the medicine or other treatment.When considering vaccinating people on immunosuppressive therapy, it is important to review the: an increased risk of adverse events, particularly from live vaccines.an increased risk of vaccine-preventable diseases or complications.reduced response to vaccines, so they may need extra doses.reduced protection from previous vaccination.It can be difficult to determine the extent to which a person is immunocompromised, because it depends on the underlying disease, medical treatment and other factors. Vaccinating people who are immunocompromised can be challenging.

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